:root {
  --header-height: 52px;
  --sidebar-width: 316px;
  --header-background: #0B1020;
  --page-background: #edf1f5;
  --panel-background: #ffffff;
  --border: #d6dde6;
  --border-strong: #aeb9c8;
  --ink: #182438;
  --muted: #59687d;
  --accent: #1769aa;
  --accent-dark: #0c4d80;
  --danger: #b42318;
  --success: #18794e;
  --warning: #9a6700;
  --card-radius: 6px;
  font-family: Inter, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
  color: var(--ink);
}

* {
  box-sizing: border-box;
}

html,
body {
  margin: 0;
  min-height: 100%;
  background: var(--page-background);
}

body {
  font-size: 14px;
  line-height: 1.45;
}

button,
input,
select {
  font: inherit;
}

button,
select,
input {
  min-height: 34px;
}

button {
  cursor: pointer;
}

button:disabled,
select:disabled {
  cursor: wait;
  opacity: 0.65;
}

a {
  color: var(--accent-dark);
}

.app-shell {
  min-height: 100vh;
}

.site-header {
  align-items: center;
  background: var(--header-background);
  color: #f5f8fc;
  display: flex;
  height: var(--header-height);
  padding: 0 12px;
}

.site-header__primary {
  align-items: center;
  display: flex;
  gap: 10px;
  min-width: 0;
}

.site-title {
  font-size: 16px;
  font-weight: 650;
  letter-spacing: 0;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.header-icon-button {
  align-items: center;
  background: transparent;
  border: 1px solid transparent;
  color: inherit;
  display: inline-flex;
  height: 32px;
  justify-content: center;
  min-height: 32px;
  padding: 0;
  width: 32px;
}

.header-icon-button:hover,
.header-icon-button:focus-visible {
  background: #1c2941;
  border-color: #52627d;
  outline: none;
}

.header-icon-button__bars {
  display: grid;
  gap: 4px;
  width: 16px;
}

.header-icon-button__bars span {
  background: currentColor;
  display: block;
  height: 2px;
  width: 16px;
}

.workspace {
  display: grid;
  gap: 10px;
  grid-template-columns: minmax(250px, var(--sidebar-width)) minmax(0, 1fr);
  padding: 10px 12px 20px;
}

.app-shell.is-sidebar-collapsed .workspace {
  grid-template-columns: minmax(0, 1fr);
}

.app-shell.is-sidebar-collapsed .sidebar-shell {
  display: none;
}

.sidebar-shell {
  align-self: start;
  background: var(--panel-background);
  border: 1px solid var(--border);
  min-width: 0;
}

.sidebar-overview,
.list-item {
  border-radius: 6px;
}

.sidebar-overview {
  padding: 17px 17px 14px;
}

.portal-kicker,
.kicker {
  color: var(--accent-dark);
  font-size: 11px;
  font-weight: 700;
  letter-spacing: 0.06em;
  text-transform: uppercase;
}

.sidebar-overview h1 {
  font-size: 20px;
  line-height: 1.2;
  margin: 5px 0 10px;
}

.sidebar-overview p,
.section-note,
.small-note,
.muted {
  color: var(--muted);
}

.sidebar-overview p {
  font-size: 13px;
  margin: 0;
}

.sidebar-stats {
  display: grid;
  gap: 7px;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  margin-top: 15px;
}

.sidebar-stat {
  background: #f5f8fb;
  border: 1px solid #e2e8f0;
  min-height: 62px;
  padding: 8px;
}

.sidebar-stat__value {
  color: #123d66;
  display: block;
  font-size: 18px;
  font-weight: 700;
  line-height: 1.05;
}

.sidebar-stat__label {
  color: var(--muted);
  display: block;
  font-size: 11px;
  margin-top: 4px;
}

.sidebar-readouts {
  border-top: 1px solid var(--border);
  padding: 14px 17px 16px;
}

.sidebar-readouts__button,
.button {
  align-items: center;
  background: #ffffff;
  border: 1px solid var(--border-strong);
  color: #1a2a40;
  display: inline-flex;
  font-size: 13px;
  font-weight: 650;
  justify-content: center;
  line-height: 1.15;
  min-height: 34px;
  padding: 7px 10px;
  text-decoration: none;
}

.sidebar-readouts__button:hover,
.button:hover {
  background: #f1f6fb;
  border-color: var(--accent);
}

.sidebar-download,
.button.primary {
  background: var(--accent-dark);
  border-color: var(--accent-dark);
  color: #ffffff;
}

.sidebar-download:hover,
.button.primary:hover {
  background: #083a62;
  border-color: #083a62;
}

.button.small {
  font-size: 12px;
  min-height: 30px;
  padding: 6px 9px;
}

.button.danger {
  color: var(--danger);
}

.sidebar-readouts__button {
  width: 100%;
}

.sidebar-readouts__list {
  color: #35465d;
  font-size: 12px;
  margin: 12px 0 9px;
  padding-left: 18px;
}

.sidebar-readouts__list li {
  margin: 5px 0;
}

.sidebar-dynamic {
  border-top: 1px solid var(--border);
  padding: 14px 17px 17px;
}

.sidebar-section + .sidebar-section {
  border-top: 1px solid #e4e9f0;
  margin-top: 13px;
  padding-top: 13px;
}

.sidebar-title {
  color: var(--muted);
  font-size: 11px;
  font-weight: 700;
  letter-spacing: 0.05em;
  text-transform: uppercase;
}

.sidebar-section h2 {
  font-size: 15px;
  line-height: 1.25;
  margin: 4px 0 9px;
}

.content-shell,
.content-frame {
  min-width: 0;
}

.content-frame {
  background: var(--panel-background);
  border: 1px solid var(--border);
}

.tabbar {
  border-bottom: 3px solid var(--header-background);
  display: flex;
  min-width: 0;
  overflow-x: auto;
  overflow-y: hidden;
  padding: 0 6px;
  white-space: nowrap;
}

.tab {
  background: transparent;
  border: 0;
  border-bottom: 3px solid transparent;
  color: #40516a;
  flex: 0 0 auto;
  padding: 8px 10px 9px;
  font-size: 14px;
  font-weight: 650;
  margin-bottom: -3px;
  min-height: 42px;
}

.tab:hover,
.tab:focus-visible {
  background: #f1f5f9;
  color: var(--accent-dark);
  outline: none;
}

.tab.active {
  border-bottom-color: var(--accent);
  color: #102a43;
}

.content-body {
  min-width: 0;
}

.tab-panel {
  display: none;
}

.tab-panel.active {
  display: block;
}

.tab-panel > div {
  min-height: 490px;
  padding: 18px;
}

.section-head {
  align-items: start;
  display: flex;
  gap: 14px;
  justify-content: space-between;
}

.section-head h2 {
  font-size: 22px;
  line-height: 1.14;
  margin: 2px 0 0;
}

.section-head h3,
.card h3,
.mini-panel h3 {
  font-size: 15px;
  line-height: 1.25;
  margin: 0;
}

.section-note {
  font-size: 13px;
  margin: 10px 0 15px;
  max-width: 1000px;
}

.summary-chip,
.status-chip {
  border: 1px solid #b9c7d8;
  color: #25466b;
  display: inline-block;
  font-size: 12px;
  font-weight: 650;
  padding: 3px 7px;
}

.control-card,
.card,
.mini-panel,
.status-panel,
.download-section,
.table-wrap {
  background: #ffffff;
  border: 1px solid var(--border);
  border-radius: var(--card-radius);
}

.control-card {
  background: #f8fafc;
  padding: 13px;
}

.control-grid {
  align-items: end;
  display: grid;
  gap: 10px;
  grid-template-columns: repeat(auto-fit, minmax(172px, 1fr));
}

.control-field {
  display: grid;
  gap: 5px;
  min-width: 0;
}

.control-field label,
.label {
  color: #4d5c70;
  font-size: 12px;
  font-weight: 700;
}

.control,
input,
select,
button.linkish {
  background: #ffffff;
  border: 1px solid var(--border-strong);
  color: var(--ink);
  font-size: 14px;
  min-height: 34px;
  padding: 6px 8px;
  width: 100%;
}

select[multiple] {
  min-height: 92px;
}

.toolbar-note {
  color: var(--muted);
  font-size: 12px;
  margin-top: 9px;
}

.grid-2,
.grid-3,
.grid-4,
.split {
  display: grid;
  gap: 12px;
}

.grid-2,
.split {
  grid-template-columns: repeat(2, minmax(0, 1fr));
}

.grid-3 {
  grid-template-columns: repeat(3, minmax(0, 1fr));
}

.grid-4 {
  grid-template-columns: repeat(4, minmax(0, 1fr));
}

.card,
.mini-panel {
  padding: 13px;
}

.stat-card {
  background: #f8fafc;
  border: 1px solid var(--border);
  min-height: 74px;
  padding: 10px;
}

.stat-value {
  color: #123d66;
  font-size: 21px;
  font-weight: 750;
  line-height: 1.05;
  overflow-wrap: anywhere;
}

.stat-label {
  color: var(--muted);
  font-size: 11px;
  margin-top: 5px;
}

.metric-stack {
  display: grid;
  gap: 8px;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  margin-top: 13px;
}

.metric-box {
  border-left: 3px solid #95b8d6;
  min-width: 0;
  padding: 5px 7px;
}

.metric-box .val {
  color: #20334d;
  font-size: 13px;
  font-weight: 700;
  overflow-wrap: anywhere;
}

.metric-box .lab {
  color: var(--muted);
  font-size: 11px;
  margin-top: 3px;
}

.gene-chip-wrap,
.chip-wrap,
.button-row,
.status-row {
  align-items: center;
  display: flex;
  flex-wrap: wrap;
  gap: 6px;
}

.gene-chip {
  background: #eaf2fa;
  border: 1px solid #c6dbef;
  color: #174b75;
  font-size: 12px;
  font-weight: 650;
  padding: 3px 6px;
}

.list {
  display: grid;
  gap: 7px;
}

.list-item {
  background: #f8fafc;
  border: 1px solid #e1e8ef;
  font-size: 12px;
  padding: 8px;
}

.bar-list {
  display: grid;
  gap: 6px;
  margin-top: 10px;
}

.bar-row {
  align-items: center;
  display: grid;
  gap: 7px;
  grid-template-columns: minmax(86px, 0.75fr) minmax(100px, 1.7fr) minmax(42px, auto);
  min-width: 0;
}

.bar-label,
.bar-value {
  font-size: 11px;
  overflow: hidden;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.bar-track {
  background: #e8edf3;
  display: block;
  height: 14px;
  overflow: hidden;
  position: relative;
}

.bar-fill {
  background: #2374b6;
  display: block;
  height: 100%;
  width: var(--bar-fill-size, 0%);
}

.bar-fill.negative {
  background: #b54b5d;
}

.bar-track.signed {
  background: linear-gradient(90deg, #f2eef5 0 49.5%, #ded8d0 49.5% 50.5%, #f7f0e8 50.5% 100%);
}

.bar-track.signed .bar-fill {
  bottom: 0;
  position: absolute;
  top: 0;
}

.bar-track.signed .bar-fill.positive {
  left: 50%;
}

.bar-track.signed .bar-fill.negative {
  right: 50%;
}

.bar-zero {
  background: #64748b;
  bottom: 0;
  display: block;
  left: calc(50% - 0.5px);
  position: absolute;
  top: 0;
  width: 1px;
  z-index: 2;
}

.selection-summary {
  color: #35465d;
  font-size: 12px;
  line-height: 1.5;
  min-height: 57px;
}

.spatial-layout {
  display: grid;
  gap: 12px;
  grid-template-columns: minmax(0, 1fr) minmax(190px, 0.45fr);
  margin-top: 14px;
}

.spatial-canvas-wrap,
.matrix-wrap,
.umap-wrap {
  background: #070b10;
  border: 1px solid #27364a;
  min-width: 0;
  position: relative;
}

.spatial-canvas {
  display: block;
  height: auto;
  max-width: 100%;
  width: 100%;
}

.spatial-canvas {
  aspect-ratio: 1;
}

.matrix-canvas {
  background: #ffffff;
  display: block;
  height: auto;
  max-width: none;
  min-height: 0;
  width: auto;
}

.matrix-wrap {
  -webkit-overflow-scrolling: touch;
  overflow-x: auto;
  overscroll-behavior-inline: contain;
}

.canvas-tooltip {
  background: #101b2b;
  border: 1px solid #95a9c1;
  color: #ffffff;
  display: none;
  font-size: 11px;
  max-width: 220px;
  padding: 7px;
  pointer-events: none;
  position: absolute;
  z-index: 5;
}

.status-panel {
  min-height: 84px;
  padding: 10px;
}

.status-panel[data-state="loading"] {
  border-left: 4px solid var(--accent);
}

.status-panel[data-state="ready"] {
  border-left: 4px solid var(--success);
}

.status-panel[data-state="empty"] {
  border-left: 4px solid #95a9c1;
}

.status-panel[data-state="error"] {
  border-left: 4px solid var(--danger);
}

.status-title {
  font-size: 12px;
  font-weight: 750;
}

.status-text {
  color: var(--muted);
  font-size: 12px;
  margin-top: 4px;
}

.legend-row {
  align-items: center;
  color: var(--muted);
  display: flex;
  font-size: 11px;
  justify-content: space-between;
  margin-top: 8px;
}

.dot-grid {
  display: grid;
  gap: 4px;
  grid-template-columns: repeat(auto-fill, minmax(17px, 1fr));
  margin-top: 10px;
}

.dot {
  background: #367fb4;
  border: 1px solid #174b75;
  border-radius: 50%;
  min-height: 17px;
  padding: 0;
}

.dot:hover,
.dot:focus-visible {
  border-color: #0a1c2f;
  outline: 2px solid #e1a24e;
}

.dot.negative {
  background: #bc5962;
  border-color: #7c2933;
}

.table-wrap {
  max-width: 100%;
  overflow: auto;
}

.table-scroll {
  max-width: 100%;
  min-width: 0;
  overflow-x: auto;
  overscroll-behavior-inline: contain;
  -webkit-overflow-scrolling: touch;
}

.table-caption {
  color: #34465f;
  font-size: 13px;
  padding: 10px 10px 0;
}

table {
  border-collapse: collapse;
  font-size: 12px;
  min-width: 680px;
  width: 100%;
}

th,
td {
  border-bottom: 1px solid #e2e8f0;
  padding: 7px 8px;
  text-align: left;
  vertical-align: top;
}

th {
  background: #f5f8fb;
  color: #3d4d63;
  font-size: 11px;
  font-weight: 750;
}

tbody tr:hover {
  background: #f8fbfe;
}

.pagination {
  align-items: center;
  display: flex;
  gap: 8px;
  justify-content: end;
  margin-top: 9px;
}

.pagination span {
  color: var(--muted);
  font-size: 12px;
}

.nested-tabs {
  border-bottom: 1px solid var(--border);
  display: flex;
  gap: 4px;
  margin-bottom: 13px;
  overflow-x: auto;
}

.nested-tab {
  background: #f5f8fb;
  border: 1px solid var(--border);
  border-bottom: 0;
  color: #40516a;
  font-size: 12px;
  min-height: 32px;
  padding: 6px 9px;
}

.nested-tab.active {
  background: #ffffff;
  color: var(--accent-dark);
  font-weight: 750;
}

.species-heatmap {
  display: grid;
  gap: 1px;
  grid-template-columns: minmax(130px, 1fr) repeat(3, minmax(72px, 0.45fr));
  margin-top: 10px;
}

.heat-cell {
  background: #eef4f9;
  color: #23364f;
  font-size: 11px;
  min-height: 28px;
  overflow: hidden;
  padding: 6px;
  text-overflow: ellipsis;
  white-space: nowrap;
}

.heat-cell.score-negative {
  background: #f4d9d9;
}

.heat-cell.score-positive {
  background: #cfe5f4;
}

.umap-wrap {
  align-items: center;
  display: flex;
  justify-content: center;
  min-height: 400px;
}

.umap-image {
  display: block;
  height: auto;
  max-width: 100%;
  width: min(620px, 100%);
}

.download-section + .download-section {
  border-top: 1px solid var(--border);
  margin-top: 16px;
  padding-top: 16px;
}

.download-section {
  border: 0;
  padding: 0;
}

.download-section h3 {
  font-size: 16px;
  margin: 0;
}

.download-section > p {
  color: var(--muted);
  font-size: 12px;
  margin: 5px 0 10px;
}

.download-row {
  align-items: center;
  border: 1px solid var(--border);
  display: grid;
  gap: 10px;
  grid-template-columns: minmax(0, 1fr) auto;
  margin-top: 8px;
  padding: 10px;
}

.download-row h4 {
  font-size: 13px;
  margin: 0;
}

.download-row p,
.download-meta {
  color: var(--muted);
  font-size: 12px;
  margin: 3px 0 0;
}

.neighborhood-downloads {
  display: flex;
  flex-wrap: wrap;
  gap: 8px;
}

.neighborhood-curve {
  overflow-x: auto;
}

.neighborhood-curve svg,
.neighborhood-network svg {
  display: block;
  min-width: 660px;
  width: 100%;
}

.neighborhood-matrix-wrap {
  overflow: auto;
}

.neighborhood-network {
  overflow-x: auto;
}

.neighborhood-axis-line,
.neighborhood-zero-line,
.neighborhood-grid-line {
  stroke: #c9d5e2;
  stroke-width: 1;
}

.neighborhood-zero-line {
  stroke: #73859a;
  stroke-dasharray: 4 3;
}

.neighborhood-grid-line {
  stroke: #e4ebf2;
}

.neighborhood-curve-line {
  fill: none;
  stroke: #87718e;
  stroke-width: 2.5;
}

.neighborhood-curve-point {
  fill: #c17c45;
  stroke: #ffffff;
  stroke-width: 2;
}

.neighborhood-axis-label {
  fill: #4d5c70;
  font-size: 11px;
}

.neighborhood-network-label {
  fill: #34485f;
  font-size: 10px;
}

.neighborhood-network-center-label {
  fill: #ffffff;
  font-size: 12px;
  font-weight: 700;
}

.loading-block,
.error-block,
.empty-block {
  background: #f8fafc;
  border: 1px solid var(--border);
  color: var(--muted);
  min-height: 100px;
  padding: 18px;
}

.view-skeleton {
  min-height: 420px;
}

.skeleton-control,
.skeleton-panel {
  background: #edf2f7;
  border: 1px solid var(--border);
}

.skeleton-control {
  border-radius: 4px;
  height: 64px;
}

.skeleton-panel {
  min-height: 260px;
}

.error-block {
  border-left: 4px solid var(--danger);
  color: #7d1c15;
}

.sr-only {
  height: 1px;
  margin: -1px;
  overflow: hidden;
  padding: 0;
  position: absolute;
  width: 1px;
}

@media (max-width: 980px) {
  .workspace {
    grid-template-columns: minmax(220px, 280px) minmax(0, 1fr);
  }

  .grid-4 {
    grid-template-columns: repeat(2, minmax(0, 1fr));
  }

  .spatial-layout {
    grid-template-columns: minmax(0, 1fr);
  }
}

@media (max-width: 720px) {
  .workspace {
    display: block;
    padding: 8px;
  }

  .sidebar-shell {
    margin-bottom: 8px;
  }

  .app-shell.is-sidebar-collapsed .sidebar-shell {
    display: none;
  }

  .content-frame {
    min-width: 0;
  }

  .tab-panel > div {
    padding: 13px;
  }

  .section-head {
    align-items: start;
    flex-direction: column;
    gap: 7px;
  }

  .section-head h2 {
    font-size: 20px;
  }

  .grid-2,
  .grid-3,
  .grid-4,
  .split {
    grid-template-columns: minmax(0, 1fr);
  }

  .download-row {
    align-items: start;
    grid-template-columns: minmax(0, 1fr);
  }

  .bar-row {
    grid-template-columns: minmax(78px, 0.8fr) minmax(84px, 1.5fr) minmax(38px, auto);
  }
}

/* UMAP initial state and aging category presentation. */
.umap-image[hidden], .umap-placeholder[hidden] { display:none; }
.umap-placeholder { display:grid; min-height:260px; margin:0; place-items:center; color:#526176; font-size:13px; background:#f8fafc; }
#aging-content .aging-legend { display:flex; flex-wrap:wrap; gap:8px 16px; font-size:12px; margin:12px 0 16px; padding:11px 13px; border:1px solid #e3e8ee; background:#f8fafc; border-radius:8px; color:#405168; }
#aging-content .aging-legend i { width:12px; height:12px; display:inline-block; border-radius:50%; flex-shrink:0; }
#aging-content .aging-legend > span { display:inline-flex; gap:6px; align-items:center; }
#aging-content .aging-link-grid { display:grid; grid-template-columns:repeat(auto-fill,minmax(min(100%,220px),1fr)); gap:12px; margin-top:14px; }
#aging-content .aging-card {
  display:flex; flex-direction:column; align-items:flex-start; gap:6px; min-height:136px; padding:14px 16px;
  border:1px solid #dfe5ec; border-left:4px solid var(--category-color); border-radius:9px;
  background:#fff; color:#203247; text-align:left; overflow-wrap:anywhere;
  transition:background-color 140ms ease,border-color 140ms ease,box-shadow 140ms ease;
}
#aging-content .aging-card-category { color:var(--category-color); font-size:11px; font-weight:700; letter-spacing:.025em; }
#aging-content .aging-card-name { font-size:14px; line-height:1.35; }
#aging-content .aging-card-program { color:#526176; font-size:12px; line-height:1.4; }
#aging-content .aging-card-metric { color:#5c6c7e; font-size:11px; font-variant-numeric:tabular-nums; margin-top:auto; padding-top:4px; }
#aging-content .aging-card:hover { border-color:var(--category-color); background:#f7f9fc; box-shadow:0 3px 10px #2032470c; }
#aging-content .aging-card.selected { background:#f0f5fa; border-color:var(--category-color); outline:2px solid var(--category-color); outline-offset:1px; }
#aging-content .aging-card.selected .aging-card-category::after { content:" · Selected"; }
#aging-content .aging-card:focus-visible { outline:3px solid #182438; outline-offset:3px; }
#aging-content .aging-selection-summary { background:#f5f8fb; border-left:4px solid var(--category-color); padding:14px 16px; border-radius:0 8px 8px 0; line-height:1.65; }
@media(prefers-reduced-motion:reduce) { #aging-content .aging-card { transition:none; } }

/* Disease associations use stable category colours and visible names. */
#disease-content .disease-legend { display:flex; flex-wrap:wrap; gap:8px 16px; margin:12px 0 16px; padding:11px 13px; border:1px solid #e3e8ee; background:#f8fafc; border-radius:8px; color:#405168; font-size:12px; }
#disease-content .disease-legend > span { display:inline-flex; gap:6px; align-items:center; }
#disease-content .disease-legend i { width:12px; height:12px; display:inline-block; border-radius:50%; flex-shrink:0; }
#disease-content .dot-grid { grid-template-columns:repeat(auto-fill,minmax(min(100%,230px),1fr)); gap:12px; }
#disease-content .disease-card {
  display:flex; flex-direction:column; align-items:flex-start; gap:6px; min-height:140px; padding:14px 16px;
  border:1px solid #dfe5ec; border-left:4px solid var(--category-color); border-radius:9px;
  background:#fff; color:#203247; text-align:left; overflow-wrap:anywhere;
  transition:background-color 140ms ease,border-color 140ms ease,box-shadow 140ms ease;
}
#disease-content .disease-card-category { color:var(--category-color); font-size:11px; font-weight:700; letter-spacing:.025em; }
#disease-content .disease-card-name { font-size:14px; line-height:1.35; }
#disease-content .disease-card-program { color:#526176; font-size:12px; line-height:1.4; }
#disease-content .disease-card-metric { color:#5c6c7e; font-size:11px; font-variant-numeric:tabular-nums; margin-top:auto; padding-top:4px; }
#disease-content .disease-card:hover { border-color:var(--category-color); background:#f7f9fc; box-shadow:0 3px 10px #2032470c; }
#disease-content .disease-card.selected { background:#f0f5fa; border-color:var(--category-color); outline:2px solid var(--category-color); outline-offset:1px; }
#disease-content .disease-card.selected .disease-card-category::after { content:" · Selected"; }
#disease-content .disease-card:focus-visible { outline:3px solid #182438; outline-offset:3px; }
#disease-content .disease-selection-summary { display:grid; gap:5px; margin-top:12px; padding:13px 14px; background:#f5f8fb; border-left:4px solid var(--category-color); border-radius:0 8px 8px 0; line-height:1.45; }
#disease-content .disease-selection-metric { color:#5c6c7e; font-size:11px; font-variant-numeric:tabular-nums; }
#disease-content [data-testid=disease-genes] .gene-chip {
  background:color-mix(in srgb,var(--category-color) 12%,white);
  border-color:color-mix(in srgb,var(--category-color) 58%,white);
  color:color-mix(in srgb,var(--category-color) 76%,#172334);
}
@media(prefers-reduced-motion:reduce) { #disease-content .disease-card { transition:none; } }

/* Shared chart presentation: category identity and numerical intensity stay distinct. */
.bar-list { gap:9px; }
.bar-row { gap:9px; }
.bar-label { white-space:normal; overflow:visible; text-overflow:clip; line-height:1.4; }
.bar-value { font-variant-numeric:tabular-nums; color:#526176; }
.bar-track { height:11px; background:#eef0f2; border-radius:4px; }
.bar-fill { background:#8060a9; border-radius:3px; }
.bar-fill.positive { background:#c17c45; }
.bar-fill.negative { background:#7b6294; }
.bar-zero { background:#8b939c; }
.bar-row:hover .bar-track { box-shadow:0 0 0 2px #dde3e9; }
.chart-category-legend { display:flex; flex-wrap:wrap; gap:7px 15px; margin:10px 0; color:#4c5c6b; font-size:11px; line-height:1.4; }
.chart-category-legend > span { display:inline-flex; align-items:center; gap:6px; }
.chart-category-legend i { display:inline-block; width:10px; height:10px; border-radius:3px; flex-shrink:0; }
.chart-legend-label { margin:8px 0 4px; font-size:11px; color:#586775; }
.plot-legend { margin:12px 0; }
.colour-legend { display:grid; gap:5px; width:280px; max-width:100%; }
.legend-label { color:#465361; font-size:12px; line-height:1.4; font-weight:600; }
.colour-ramp { display:block; height:11px; border:1px solid #e0ddd5; border-radius:3px; }
.legend-ticks { display:flex; justify-content:space-between; gap:12px; font-size:11px; color:#586775; font-variant-numeric:tabular-nums; }
.matrix-wrap { border-color:#dce2e7; background:#fff; }
.heat-cell { background:#f6f7f8; color:#293b4a; font-variant-numeric:tabular-nums; }
.heat-cell.score-negative { background:#e9e1f0; color:#644f7b; }
.heat-cell.score-positive { background:#f3e4d5; color:#8b5837; }
.heat-cell.layer-cell { background:color-mix(in srgb,var(--layer-colour) 17%,white); color:color-mix(in srgb,var(--layer-colour) 78%,#15242e); border-left:3px solid var(--layer-colour); font-weight:600; }
#species-content .heat-cell { white-space:normal; overflow-wrap:anywhere; line-height:1.4; }

/* Default gene example uses the existing result table, not a new analysis. */
#gene-content .gene-example-note { margin:0; padding:15px 17px; background:#faf5ef; border-left:4px solid #a8784f; color:#66584f; font-size:12px; line-height:1.65; }
#gene-content .gene-example-note b { color:#654d6b; font-size:14px; }

/* Direct selections keep original values and ordering; no hidden chart filters. */
.bar-row { width:100%; border:0; padding:3px 4px; background:transparent; color:inherit; text-align:left; border-radius:5px; min-height:26px; font:inherit; cursor:pointer; }
.bar-row:hover { background:#faf6f0; }
.bar-row.selected { background:#f2e9dc; outline:1px solid #c6aa86; }
.bar-row:focus-visible,.relation-row:focus-visible { outline:2px solid #775c8c; outline-offset:2px; }
.chart-selection-readout,.canvas-readout { margin:10px 0; padding:10px 13px; background:#faf5ef; border-left:3px solid #ac8258; color:#53483f; line-height:1.55; font-size:12px; }
.chart-selection-readout { font-variant-numeric:tabular-nums; }
.matrix-tools { display:flex; gap:6px; align-items:center; margin:8px 0; flex-wrap:wrap; font-size:11px; color:#695d50; }
.matrix-tools span { margin-right:auto; }
.interactive-matrix-wrap { position:relative; overflow:auto; max-height:72vh; }
.matrix-selection-box { position:absolute; border:2px solid #33243c; box-shadow:0 0 0 1px #fff; pointer-events:none; z-index:2; }
.local-relations { margin-top:12px; }
.local-relations-heading { display:flex; align-items:center; justify-content:space-between; gap:15px; padding:12px 14px; background:#f6f0e9; border-radius:7px; color:#56405f; }
.relation-row,.relation-column-labels { display:grid; grid-template-columns:minmax(170px,1fr) 66px 112px 95px; gap:16px; align-items:center; width:100%; }
.relation-column-labels { padding:9px 14px; color:#7a6d61; font-size:10px; }
.relation-row { padding:11px 14px; background:white; border:0; border-bottom:1px solid #ede7df; border-radius:0; text-align:left; font:inherit; color:#403b37; cursor:pointer; min-height:56px; }
.relation-row:hover { background:#faf6f0; }
.relation-row.selected { background:#f3e8d9; box-shadow:inset 3px 0 var(--relation-colour); }
.relation-partner { font-size:12px; line-height:1.45; white-space:normal; overflow-wrap:anywhere; }
.relation-edge { display:block; height:var(--relation-width); background:var(--relation-colour); border-radius:3px; position:relative; }
.relation-edge::before,.relation-edge::after { content:""; position:absolute; width:7px; height:7px; border-radius:50%; background:var(--relation-colour); top:50%; transform:translateY(-50%); }
.relation-edge::before { left:0; } .relation-edge::after { right:0; }
.relation-direction { color:var(--relation-colour); font-size:11px; }
.relation-value { text-align:right; font-variant-numeric:tabular-nums; font-size:12px; }
.neighborhood-curve-point { cursor:pointer; }
.neighborhood-curve-point.selected,.neighborhood-curve-point:focus-visible { stroke:#473151!important; stroke-width:3px; }
@media(max-width:680px) { .relation-row,.relation-column-labels { grid-template-columns:minmax(110px,1fr) 32px 70px 54px; gap:8px; } .relation-direction{font-size:10px;} .relation-partner{font-size:11px;} }

.neighborhood-explorer { display:grid; grid-template-columns:minmax(0,1.05fr) minmax(350px,1fr); grid-template-rows:auto auto; gap:14px; margin:14px 0; align-items:start; }
.neighborhood-explorer>.mini-panel { margin:0!important; padding:14px; min-width:0; }
.neighborhood-overview { grid-column:1; grid-row:1 / span 2; position:sticky; top:10px; }
.neighborhood-local { grid-column:2; grid-row:1; }
.neighborhood-profile { grid-column:2; grid-row:2; scroll-margin-top:12px; }
.neighborhood-local .relation-row,.neighborhood-local .relation-column-labels { grid-template-columns:minmax(110px,1fr) 42px 70px 60px; gap:8px; }
.neighborhood-local .relation-row { padding:8px 7px; min-height:43px; }
.neighborhood-local .relation-partner { font-size:11px; }
.neighborhood-local .relation-direction,.neighborhood-local .relation-value { font-size:10px; }
.neighborhood-local .local-relations-heading { padding:9px; font-size:12px; align-items:start; }
.neighborhood-profile .neighborhood-curve { overflow:visible; }
.neighborhood-profile .neighborhood-curve svg { min-width:0; width:100%; height:auto; }
.neighborhood-stat-strip { display:flex; flex-wrap:wrap; gap:0; padding:7px 0; background:#faf7f3; border:1px solid #ece5dc; border-radius:6px; }
.neighborhood-stat-strip>.metric-card { min-height:0; border:0; background:none; padding:3px 14px; display:flex; flex-direction:row; gap:7px; align-items:baseline; }
.neighborhood-stat-strip .metric-value { font-size:16px; }
@media(max-width:1100px) { .neighborhood-explorer { grid-template-columns:minmax(0,1fr); } .neighborhood-overview,.neighborhood-local,.neighborhood-profile { grid-column:1; grid-row:auto; position:static; } }

/* Direct spatial-bin interactions retain the original geometry and scores. */
.point-tools { display:flex; flex-wrap:wrap; gap:6px; align-items:center; margin:8px 0; font-size:11px; color:#746454; }
.point-tools>span { flex:1; min-width:180px; }
.point-interactive-canvas { cursor:crosshair; }
.point-interactive-canvas.is-panning { cursor:grabbing; }
.category-key { display:inline-flex; gap:5px; align-items:center; font:inherit; color:inherit; border:1px solid transparent; background:transparent; border-radius:4px; padding:4px 6px; cursor:pointer; }
.category-key i { display:inline-block; width:10px; height:10px; border-radius:50%; }
.category-key:hover,.category-key.selected { background:#f4e9dd; border-color:#bfa181; }
.category-key:focus-visible { outline:2px solid #7b6294; }
.neighborhood-stat-strip>.stat-card { min-height:0; border:0; background:none; padding:3px 14px; display:flex; gap:7px; align-items:baseline; }
.neighborhood-stat-strip .stat-value { font-size:16px; }

/* Original UMAP points, with the existing dominant-program image retained. */
.umap-controls .control-grid{grid-template-columns:minmax(150px,.8fr) minmax(220px,1.5fr) auto;align-items:end;}
.umap-state-line{display:flex;gap:10px;align-items:baseline;padding:10px 0;color:#76604d;font-size:12px;}
.umap-state-line[data-state=error]{color:#ad4d4b;}
.umap-explorer{display:grid;grid-template-columns:minmax(0,1fr) 190px;gap:18px;align-items:start;}
.umap-main{min-width:0;}
.umap-point-wrap{position:relative;width:100%;min-height:260px;background:#fbf8f3;border:1px solid #e6ded2;border-radius:7px;overflow:hidden;}
.umap-point-canvas{display:block;width:100%;height:auto;cursor:crosshair;touch-action:none;}
.umap-point-canvas.is-panning{cursor:grabbing;}
.umap-point-canvas[hidden],.umap-image[hidden],.umap-point-tools[hidden]{display:none!important;}
.umap-point-tools{position:absolute;top:10px;left:10px;display:flex;flex-wrap:wrap;gap:4px;}
.umap-point-tools .button{background:#fffdf9;padding:6px 9px;box-shadow:0 1px 3px #46372112;}
.umap-legend-panel{border-left:2px solid #c9b29a;padding-left:14px;min-width:0;}
.umap-legend-panel h3{margin-top:2px;font-size:13px;line-height:1.5;}
.umap-category-keys{display:flex;flex-direction:column;gap:2px;font-size:11px;}
.umap-category-keys .category-key{text-align:left;line-height:1.35;}
.umap-category-keys .category-key i{flex-shrink:0;}
.umap-legend-panel .colour-legend{display:block;}
.umap-legend-panel .colour-ramp{width:100%;display:block;margin:10px 0 5px;}
.umap-legend-panel .legend-ticks{display:flex;justify-content:space-between;width:100%;font-size:10px;}
.umap-main .canvas-readout{overflow-wrap:anywhere;margin:10px 0 0;}
@media(max-width:1050px){.umap-explorer{grid-template-columns:minmax(0,1fr);}.umap-category-keys{flex-direction:row;flex-wrap:wrap;}.umap-legend-panel{border-left:0;border-top:1px solid #dfd2c0;padding:12px 0;}.umap-legend-panel .colour-ramp,.umap-legend-panel .legend-ticks{max-width:260px;}}
@media(max-width:680px){.umap-controls .control-grid{grid-template-columns:1fr;}.umap-point-tools .button{font-size:10px;padding:5px;}}

#gene-content .control-card{padding:16px 18px;margin-bottom:14px;}
#gene-content [data-testid=gene-results]{border:0;background:transparent;overflow:visible;}
#gene-content .gene-example-note{margin:0 0 18px;padding:17px 20px;background:#faf3ec;border:1px solid #e9dacf;border-left:4px solid #ae8275;border-radius:6px;color:#655162;line-height:1.7;}
#gene-content .gene-example-note b{color:#6f466f;font-size:16px;}
#gene-content .table-caption{padding:0 5px 10px;color:#52404d;}
#gene-content table{border:1px solid #dfd3d9;border-radius:6px;overflow:hidden;}
#gene-content thead{background:#f6f1ed;}
#gene-content tbody tr:hover,#gene-content tbody tr:focus-within,#gene-content tr.gene-selected{background:#f1e7f0;}
#gene-content .text-link{border:0;background:transparent;text-align:left;color:#6f466f;font:inherit;cursor:pointer;padding:3px 0;}
#gene-content .text-link:hover{text-decoration:underline;}

/* Shared research-page composition: thin separators, warm field, and readable evidence flow. */
body{background:#f3f0eb;}
.research-page{--research-ink:#392f36;--research-muted:#756a65;--research-line:#e3d9cf;--research-wash:#fbf7f2;color:var(--research-ink);}
.research-page>.section-head{margin-bottom:5px;}
.research-page>.section-note{max-width:940px;margin-top:4px;}
.research-page .control-card{background:var(--research-wash);border:1px solid var(--research-line);box-shadow:none;padding:12px 14px;}
.research-page .control-grid{display:flex;flex-wrap:wrap;align-items:end;gap:10px;}
.research-page .control-grid>.control-field{flex:1 1 170px;min-width:150px;}
.research-page .control-grid>.button,.research-page .control-grid>.control-field:has(.button){flex:0 0 auto;}
.research-page .mini-panel,.research-page .card{border:1px solid var(--research-line);box-shadow:none;border-radius:8px;background:#fffdfa;}
.research-page .mini-panel h3,.research-page .card h3{color:#473a44;}
.research-page table{font-variant-numeric:tabular-nums;}
.research-page table th,.research-page table td{border-bottom-color:#e7ded5;}
.research-page .category-legend{gap:8px 14px;}
.research-page .category-legend span{white-space:normal;}
.research-page .status-panel{box-shadow:none;}
/* Program: evidence summaries at left, large original spatial field at right. */
.research-page-program .section-head{align-items:end;gap:12px;flex-wrap:wrap;}
.research-page-program .program-picker{min-width:min(430px,100%);}
.research-page-program .program-intro{margin:9px 0 12px;background:var(--research-wash);border:1px solid var(--research-line);padding:13px 15px;border-radius:8px;}
.research-page-program .identity-line{margin:5px 0 8px;}
.research-page-program .grid-4{display:flex;flex-wrap:wrap;border:1px solid var(--research-line);border-radius:7px;background:#fcf9f5;gap:0!important;}
.research-page-program .grid-4>.stat-card{flex:1 1 150px;border:0;border-right:1px solid var(--research-line);background:transparent;min-height:0;padding:9px 13px;}
.research-page-program .program-primary-grid{display:grid;grid-template-columns:minmax(320px,.82fr) minmax(480px,1.18fr);gap:14px;margin:14px 0;align-items:start;}
.research-page-program .program-usage-column{display:grid!important;grid-template-columns:1fr!important;gap:12px!important;margin:0!important;}
.research-page-program .program-usage-column>.mini-panel{margin:0!important;padding:13px;}
.research-page-program .program-spatial-primary{margin:0!important;padding:13px;position:sticky;top:8px;}
.research-page-program .program-spatial-primary .spatial-canvas,.research-page-program .program-spatial-primary canvas{width:100%;height:auto;}
.research-page-program .program-secondary-grid{gap:14px!important;margin:14px 0!important;}
.research-page-program .program-secondary-grid>.mini-panel{margin:0!important;}
.research-page-program .annotation-metrics,.research-page-program .metric-stack{display:flex;flex-wrap:wrap;gap:8px;}
.research-page-program .functional-details,.research-page-program [data-testid=program-functional]{margin-top:14px;}
/* Matrices: keep every program row large enough to read and use the existing scroll/zoom tools. */
.research-page-matrices .matrix-toolbar{display:flex;flex-wrap:wrap;gap:16px;align-items:end;background:var(--research-wash);border:1px solid var(--research-line);padding:11px 14px;border-radius:7px;}
.research-page-matrices .matrix-toolbar>.control-field{min-width:240px;}
.research-page-matrices .matrix-primary-panel{margin-top:12px!important;padding:13px;}
.research-page-matrices .matrix-primary-panel .interactive-matrix-wrap,.research-page-matrices .matrix-primary-panel .matrix-wrap{max-height:76vh;overflow:auto;background:#fffdfa;border-top:1px solid var(--research-line);}
.research-page-matrices .matrix-tools{position:sticky;top:0;z-index:4;background:#fffdfa;padding:7px 0;margin:0;}
.research-page-matrices .canvas-tooltip{max-width:260px;white-space:normal;}
/* Spatial: one large field, a compact outside legend/readout, no oversized status card. */
.research-page-spatial .spatial-reading-grid,.research-page-spatial .spatial-layout{display:grid;grid-template-columns:minmax(520px,1fr) minmax(210px,270px);gap:14px;align-items:start;margin-top:12px;}
.research-page-spatial .spatial-interactive-panel{min-width:0;}
.research-page-spatial .spatial-canvas-wrap{background:#fbf8f3;border:1px solid var(--research-line);border-radius:7px;overflow:hidden;}
.research-page-spatial .spatial-canvas{display:block;width:100%;height:auto;}
.research-page-spatial .spatial-side-panel{border-left:2px solid #c4a98d;padding-left:13px;}
.research-page-spatial .compact-status{display:flex;gap:8px;align-items:baseline;padding:8px 0;border:0;background:transparent;}
.research-page-spatial .compact-status .status-title{white-space:nowrap;}
.research-page-spatial .spatial-side-legend{margin-top:9px;}
.research-page-spatial .spatial-readout,.research-page-spatial .canvas-readout{margin-top:8px;}
/* Disease: named associations remain all visible and read directly with their selected genes. */
.research-page-disease .control-card .control-grid{align-items:start;}
.research-page-disease select[multiple]{min-height:78px;}
.research-page-disease .disease-reading-grid{display:grid;grid-template-columns:minmax(0,1.25fr) minmax(310px,.75fr);gap:14px;margin-top:12px;align-items:start;}
.research-page-disease .disease-card-panel{margin:0!important;}
.research-page-disease .disease-detail-panel{margin:0!important;position:sticky;top:8px;}
.research-page-disease .dot-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:8px;}
.research-page-disease .disease-card{min-height:104px;padding:11px 12px;border:1px solid var(--research-line);border-left:4px solid var(--category-color);border-radius:7px;background:#fffdfa;text-align:left;}
.research-page-disease .disease-card.selected{outline:2px solid var(--category-color);outline-offset:1px;background:#faf2ec;}
.research-page-disease .disease-card.selected::after{content:"Selected";display:block;margin-top:7px;color:var(--category-color);font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em;}
.research-page-disease .disease-card-category,.research-page-disease .disease-card-program,.research-page-disease .disease-card-metric{display:block;line-height:1.45;}
.research-page-disease .disease-card-name{display:block;margin:4px 0;color:#43343e;}
.research-page-disease .disease-card-metric{font-variant-numeric:tabular-nums;}
.research-page-disease .selection-summary{border-left:4px solid var(--category-color);background:#faf5ef;}
/* Aging: same evidence grammar as Disease, with selected set and genes alongside all cards. */
.research-page-aging .study-summary-line,.research-page-aging>.grid-4{display:flex;flex-wrap:wrap;gap:0;border:1px solid var(--research-line);border-radius:7px;background:#fcf9f5;margin:10px 0 12px;}
.research-page-aging .study-summary-line>span,.research-page-aging>.grid-4>.stat-card{flex:1 1 150px;padding:9px 13px;border:0;border-right:1px solid var(--research-line);background:transparent;min-height:0;}
.research-page-aging .aging-reading-grid{display:grid;grid-template-columns:minmax(0,1.25fr) minmax(310px,.75fr);gap:14px;margin-top:12px;align-items:start;}
.research-page-aging .aging-card-panel,.research-page-aging .aging-detail-panel{margin:0!important;}
.research-page-aging .aging-detail-panel{position:sticky;top:8px;}
.research-page-aging .aging-link-grid{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:8px;}
.research-page-aging .aging-card{min-height:104px;padding:11px 12px;border:1px solid var(--research-line);border-left:4px solid var(--category-color);border-radius:7px;background:#fffdfa;text-align:left;}
.research-page-aging .aging-card.selected{outline:2px solid var(--category-color);outline-offset:1px;background:#faf2ec;}
.research-page-aging .aging-card.selected::after{content:"Selected";display:block;margin-top:7px;color:var(--category-color);font-size:10px;font-weight:700;text-transform:uppercase;letter-spacing:.05em;}
.research-page-aging .aging-card-category,.research-page-aging .aging-card-program,.research-page-aging .aging-card-metric{display:block;line-height:1.45;}
.research-page-aging .aging-card-name{display:block;margin:4px 0;color:#43343e;}
.research-page-aging .aging-selection-summary{border-left:4px solid var(--category-color);background:#faf5ef;}
/* Downloads: a three-part ledger; every retained row keeps description, file identity and action. */
.research-page-downloads .download-guidance{padding:11px 14px;background:#faf4ec;border-left:4px solid #9d6f67;color:#5f5151;}
.research-page-downloads .download-section{margin:15px 0 0;padding:0;border:1px solid var(--research-line);border-radius:8px;background:#fffdfa;overflow:hidden;}
.research-page-downloads .download-section>h3{margin:0;padding:13px 15px 2px;}
.research-page-downloads .download-section>p{margin:0;padding:0 15px 11px;color:var(--research-muted);}
.research-page-downloads .download-row{display:grid;grid-template-columns:minmax(0,1fr) auto;gap:18px;align-items:center;margin:0;padding:13px 15px;border:0;border-top:1px solid var(--research-line);border-radius:0;background:transparent;}
.research-page-downloads .download-row h4{margin:0 0 3px;color:#473945;}
.research-page-downloads .download-row p{margin:0 0 5px;color:var(--research-muted);}
.research-page-downloads .download-meta{font-variant-numeric:tabular-nums;color:#826e62;}
.research-page-downloads .download-row .button{min-width:104px;text-align:center;}
@media(max-width:1150px){
 .research-page-program .program-primary-grid,.research-page-disease .disease-reading-grid,.research-page-aging .aging-reading-grid{grid-template-columns:1fr;}
 .research-page-program .program-spatial-primary,.research-page-disease .disease-detail-panel,.research-page-aging .aging-detail-panel{position:static;}
 .research-page-spatial .spatial-reading-grid,.research-page-spatial .spatial-layout{grid-template-columns:1fr;}
 .research-page-spatial .spatial-side-panel{border-left:0;border-top:1px solid var(--research-line);padding:10px 0 0;}
}
@media(max-width:720px){
 .research-page-disease .dot-grid,.research-page-aging .aging-link-grid{grid-template-columns:1fr;}
 .research-page-downloads .download-row{grid-template-columns:1fr;}
 .research-page-downloads .download-row .button{justify-self:start;}
 .research-page .control-grid>*{flex-basis:100%!important;}
}

/* Keep selected evidence and genes readable in the narrow companion column. */
.research-page-disease .disease-detail-panel,.research-page-aging .aging-detail-panel{display:grid!important;grid-template-columns:1fr!important;gap:10px!important;}
.research-page-disease select[multiple]{min-height:104px;}